Dalmelitinib Plus Aumolertinib Improves Progression-Free Survival Over Platinum Chemotherapy (6.2 vs 4.4 Months) in EGFR-Mutated, MET-Amplified NSCLC After EGFR-TKI Progression, With Overall Survival Still Immature: A Randomized, Open-Label Phase 3 Trial

How this article was produced

This article was written about a single named primary publication, with AI assistance for literature discovery, drafting and editing. AI tools are not the author and are not responsible for the conclusions.

How the draft was prepared

• Discovery: PubMed is searched for oncology publications from the previous 14 days in a fixed list of major journals — JAMA Oncology, The Lancet Oncology, Journal of Clinical Oncology, Annals of Oncology, Nature Reviews Clinical Oncology, New England Journal of Medicine, Nature Medicine, Cancer Discovery and Clinical Cancer Research — falling back to a named set of open-access journals only if that list yields nothing. Candidates are ranked by how completely they report quantitative results, and studies already covered are excluded.
• Source: the article is drafted from the open full text in PubMed Central where one exists. Where only the abstract is available, it is supplemented with cited external sources — the trial registry record, conference abstracts, sponsor releases — and facts drawn from those sources are labelled as such.
• Numbers are reported exactly as the source gives them, with confidence intervals and p-values, and are not rounded. Data the source does not report is stated as not specified rather than estimated.
• Subgroup statistics are reported only where the source states them explicitly, and quotations are reproduced verbatim.
• Benchmarks from other studies are labelled as cross-study comparisons and never presented as results of the trial itself.
• Validation: every factual claim in the draft is checked against the source, and key claims are spot-checked against independent sources such as the trial registry. Fixable discrepancies are corrected before the draft is handed on for publication.

These steps are instructions followed by an AI system, not checks enforced by software. The validation step is itself performed by AI rather than a person, and its verdict does not by itself stop an article from being published. This describes the current workflow; some earlier articles predate parts of it.

Checks completed before publication

• The primary publication is recorded in structured form — journal, publication date, DOI, PubMed ID and PMC ID where they exist — rather than only as prose in a reference list.
• Every cited DOI is confirmed to resolve.
• Every cited PubMed ID is confirmed to exist in PubMed.
• The cited DOI is cross-checked against the DOI that PubMed records for that PubMed ID, so a citation cannot point at a different paper from the one the article describes.
• Trial registry identifiers are format-checked and linked to their ClinicalTrials.gov record.
• Every reference must carry a resolvable identifier or link, unless it is explicitly labelled as a funding note, press release or background statistic.
• The article must contain a limitations discussion specific to the study — what it could not establish — not a generic disclaimer.
• Absolutist claims such as “proves”, “guarantees”, “will cure” or “completely effective” are rejected.
• HTML markup and entities that would render as literal text — such as an unsupported tag or " " — are rejected outside the reference list.
• Structural checks confirm the article has a unique URL and complete metadata.

These run automatically on every article. If any of them fails, the build fails and the article is held rather than published.

What these checks do not cover

These checks confirm that the sources are real and correctly cited. They do not confirm that the analysis drawn from them is sound. This article has not been read against its primary source by a human editor, and should be read as a signpost to the primary publication rather than a substitute for it.

Evidence note

This article summarizes research findings and does not provide medical advice or treatment recommendations. Investigational findings, preliminary results, and preclinical evidence should not be interpreted as established clinical care. Always consult the cited primary source, and a qualified clinician, before acting on anything described here.

Corrections

Report a factual error or a sourcing concern through our corrections policy. Substantive corrections are dated and described on the article page. Our editorial policy explains how these articles are sourced, verified, and corrected.